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Dominique Modrowski Selected Research

Syndecan-2

1/2017Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells.
1/2015Role of syndecan-2 in osteoblast biology and pathology.
10/2012Targeted inhibition of T-cell factor activity promotes syndecan-2 expression and sensitization to doxorubicin in osteosarcoma cells and bone tumors in mice.
6/2012Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.
7/2010High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells.
4/2007Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma.
8/2005Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling.

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Dominique Modrowski Research Topics

Disease

9Osteosarcoma (Osteogenic Sarcoma)
01/2022 - 08/2005
7Neoplasms (Cancer)
01/2022 - 08/2005
1Bone Resorption
01/2017
1Osteoarthritis
05/2016
1Hypertrophy
05/2016
1Hypoxia (Hypoxemia)
05/2016
1Cystic Fibrosis (Mucoviscidosis)
07/2015
1Neoplasm Metastasis (Metastasis)
05/2013
1Infections
10/2012
1Lymphoma (Lymphomas)
10/2012
1Carcinogenesis
10/2012
1Metabolic Bone Diseases (Osteopenia)
01/2004
1Osteoporosis
01/2004

Drug/Important Bio-Agent (IBA)

7Syndecan-2IBA
01/2017 - 08/2005
3CateninsIBA
07/2015 - 10/2012
3Small Interfering RNA (siRNA)IBA
05/2013 - 06/2012
3Doxorubicin (Adriamycin)FDA LinkGeneric
10/2012 - 04/2007
2Cytotoxins (Cytolysins)IBA
01/2015 - 06/2012
2Proteins (Proteins, Gene)FDA Link
05/2013 - 10/2012
2Methotrexate (Mexate)FDA LinkGeneric
06/2012 - 04/2007
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2012 - 01/2004
2Proteoglycans (Proteoglycan)IBA
06/2012 - 07/2010
1MicroRNAs (MicroRNA)IBA
01/2022
1DNA (Deoxyribonucleic Acid)IBA
01/2022
1RNA (Ribonucleic Acid)IBA
01/2022
1LigandsIBA
01/2017
1NF-kappa B (NF-kB)IBA
01/2017
1Metalloproteases (Metalloproteinases)IBA
05/2016
1Oxygen (Dioxygen)IBA
05/2016
1Matrix Metalloproteinases (MMPs)IBA
05/2016
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
10/2012
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2012
1UbiquitinIBA
10/2012
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
10/2012
1Proto-Oncogene Proteins c-cblIBA
10/2012
1TCF Transcription FactorsIBA
10/2012
1ErbB Receptors (EGF Receptor)IBA
10/2012
1Endothelin-1 (Endothelin 1)IBA
06/2012
1CytokinesIBA
06/2012
1A-Form DNA (A-DNA)IBA
07/2010
1matrigelIBA
04/2007
1Cisplatin (Platino)FDA LinkGeneric
04/2007
1Messenger RNA (mRNA)IBA
04/2007
1SyndecansIBA
08/2005
1Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
01/2004
1Transforming Growth Factor beta (TGF-beta)IBA
01/2004
1Anabolic AgentsIBA
01/2004

Therapy/Procedure

4Drug Therapy (Chemotherapy)
05/2013 - 04/2007